In the town of Kingsbridge, a Gothic cathedral and the priory are at the center of a web of love and hate, greed and pride, ambition and revenge. Proponents of the old ways fiercely battle those with progressive minds, as the Black Death captures the city.

In 1348 England, as the plague ravages the country, nine desperate strangers attempt to outrun the Black Death, revealing their individual stories as they travel away from the devastation, but one among them is hiding a far more sinister secret.