Abbott and Costello are working as railroad clerks and receive a shipment containing the last remains of Dracula and Frankenstein. When the remains disappear the clerks are blamed.

It's 1957, and Hollywood horror director James Whale's heyday as the director of "Frankenstein," "Bride of Frankenstein" and "The invisible man" is long behind him. Retired and a semi-recluse, he lives his days accompanied only by images from his past. When his dour housekeeper Hannah hires handsome young gardener Clayton Boone, the gay director and the simple yardman develop an unlikely friendship.

Baron Frankenstein is blackmailed by Dr. Praetorious into reviving his monster and building a mate for it.